How to take Calocurb

Dosing Protocols

Select your situation below to see the recommended protocol, dosing schedule, and what to expect. All protocols were developed with healthcare practitioners.

Protocol

Stopping GLP-1 Medications

Designed for people tapering off or discontinuing semaglutide, tirzepatide, or other GLP-1 receptor agonists — and those who've reached their goal weight.

Step-up dosing schedule

Time of day Days 1–7 Day 8+
AM — 1 hr before breakfast*
PM — 1 hr before largest meal

* Or the first meal of the day. Add 1 capsule in the evening if night-time snacking is a concern.

Max 4 capsules daily. Best results on an empty stomach. People coming off GLP-1 RAs generally tolerate Calocurb well — you can ramp up faster than the standard schedule if you feel comfortable.

When you stop a GLP-1 medication, your body faces a double challenge: the drug is gone, and your natural GLP-1 production has been suppressed by the medication (typically within 14 weeks of starting it). This is why most people regain weight after stopping — it's not a willpower issue.

Starting Calocurb during the final week of your last injection gives your natural satiety signals a chance to recover. Amarasate® stimulates the same GLP-1/CCK/PYY pathway as the medication, helping to bridge the transition.

Begin Calocurb during the same week as your last injection. If you're on oral GLP-1 medication, start during the final week of your usual dose.

Because your gut has already been sensitised by the GLP-1 RA, most people tolerate Calocurb with fewer initial GI effects than someone starting from scratch.

Some people notice a mild laxative effect when first starting — this usually resolves within 24–48 hours. If this occurs, reduce to 1 capsule per dose and increase again after 2–3 days.

Most users report feeling fuller more quickly and experiencing quieter "food noise" within the first week. Results are best when taken on a genuinely empty stomach.

For educational guidance only. This protocol was developed in collaboration with healthcare practitioners to support individualized treatment planning. It is not a substitute for medical advice and should be adapted to individual patient needs. Consult a qualified healthcare professional before use.

Protocol

Using Calocurb with GLP-1 Medications

For people on semaglutide or tirzepatide who want to maintain natural GLP-1 production and potentially reduce their medication dose over time.

Standard dose (injectable GLP-1 RA)

Time of day Week 2 onwards
AM — 1 hr before breakfast*
PM — 1 hr before last meal

Micro-dose or oral GLP-1 RA

Time of day Week 2–6 Week 6+
AM — 1 hr before breakfast*
Adjust to your needs
PM — 1 hr before last meal
—

* Or the first meal of the day. After 4 weeks on micro-dosing protocol, adjust based on your individual needs. Add 1 capsule in the evening if night-time snacking is a problem.

Max 4 capsules daily. Start Calocurb in week 2 of your GLP-1 RA — not week 1. Always swallow whole on an empty stomach.

GLP-1 medications suppress your body's own natural GLP-1 production — typically within 14 weeks. Calocurb stimulates your gut cells to produce GLP-1 via a different mechanism (bitter receptor activation), helping to maintain natural production during treatment.

Some practitioners report that patients using Calocurb alongside GLP-1 RAs are able to achieve comparable results at lower medication doses — potentially reducing side effects.

Most people tolerate Calocurb well when already on a GLP-1 RA. Begin in week 2 — not week 1 — to let your body adjust to the medication first.

If you experience increased GI symptoms, reduce to 1 capsule per dose and increase gradually. Add an evening capsule if late-night eating is a challenge.

For educational guidance only. Developed in collaboration with healthcare practitioners. Not a substitute for medical advice. Always consult your prescribing healthcare provider before adding any supplement to a prescription medication regimen.

Protocol

Peri-Menopause & Menopause

For women experiencing hormonal weight changes, increased appetite, and shifts in body composition during the menopause transition.

Step-up dosing schedule

Time of day Days 1–2 Days 3–4 Day 5+
AM — 1 hr before a meal
PM — 1 hr before a meal
Max 4 capsules daily. Best results on an empty stomach. Combining Calocurb with moderate aerobic exercise and increased dietary protein supports the best outcomes.

As estrogen levels decline, the brain's satiety signalling weakens — you feel less satisfied from the same meals, and cravings (especially for sweets) increase. Studies show women gain an average of 3.3 lbs per year during the menopause transition, often shifting from a pear to an apple body shape.

GLP-1 is one of the key hormones that signals fullness after eating. Because estrogen supports GLP-1 sensitivity, its decline means the "I'm full" message gets quieter. Calocurb works directly on gut GLP-1 production, helping to restore that signal.

  • Aim for roughly 200 fewer calories per day — small portion reductions at each meal add up without feeling like deprivation
  • Increase protein proportion of your diet to support muscle maintenance and satiety
  • Moderate aerobic exercise plus strength training helps counteract muscle loss and slowing metabolism
  • Calocurb can be used alongside HRT — speak with your healthcare provider about combining approaches
For educational guidance only. Developed in collaboration with practitioners. Not a substitute for medical advice. Individual patient needs vary — consult a qualified healthcare professional, particularly if you are using hormone replacement therapy.

Protocol

Portion Control & Weight Management

For people looking to reduce meal size, feel full faster, and create a sustainable daily calorie deficit without strict dieting.

Step-up dosing schedule

Time of day Days 1–2 Days 3–4 Day 5+
AM — 1 hr before a meal
PM — 1 hr before a meal
Max 4 capsules daily. Use portion control plates if available, or smaller plates at home to reinforce the satiety signal.

Even small reductions in meal size — cutting 100 calories from each — can create a daily deficit of 300–600 calories, equating to 0.7–1.3 lbs of loss per week.

Calocurb's Amarasate® activates bitter taste receptors (TAS2Rs) in the gut, triggering GLP-1, CCK, and PYY release — the "I'm full" hormone cascade. In clinical studies, this doubled the normal post-meal GLP-1 rise and reduced subsequent food intake by nearly 20%.

For educational guidance only. Developed in collaboration with practitioners. Not a substitute for medical advice. Not intended to diagnose, treat, or prevent any medical condition.

Protocol

Intermittent Fasting

For people using 5:2, alternate-day, time-restricted eating, or water-only fasting — where hunger and cravings are the biggest barrier to consistency.

Dosing by fasting type

Fasting type When to take How many
Reduced calorie days (5:2, alternate day) 1 hr before missed meal, or before reduced-calorie meals
Time-restricted eating (TRE) During your fasting window, at 4-hr intervals if needed
Water-only fasting 1 hr before when you'd normally eat
Max 6 capsules on reduced-calorie days. Always start at 1 capsule and increase gradually. Take on a genuinely empty stomach for best results.
  • TRE eating window 12pm–8pm: take Calocurb at 8am (during fasting window)
  • TRE eating window 9am–5pm: take Calocurb at 8pm (after eating window closes)
  • Increase frequency to every 4 hours during fasting if hunger is significant

Intermittent fasting reduces fullness hormones including GLP-1 and leptin, which is why people often feel hungry during fasting periods. In clinical trials, Calocurb reduced both overall hunger and cravings during 24-hour water-only fasts — reducing hunger by 30% in women and 20% in men.

For educational guidance only. Developed in collaboration with practitioners. Not a substitute for medical advice. Individual needs vary — adjust dosing based on your fasting pattern and tolerance.

Protocol

Using Calocurb If You Have PCOS

For women managing weight, appetite, and eating behavior as part of their PCOS management plan.

Step-up dosing schedule

Time of day Days 1–2 Days 3–4 Day 5+
AM — 1 hr before a meal
PM — 1 hr before a meal
Max 4 capsules daily. Swallow whole with a full glass of water on an empty stomach. Always follow your healthcare provider's guidance on food, exercise, and medications.

PCOS affects 10–13% of women and is closely linked to overweight/obesity — 50–80% of women with PCOS live with these conditions. Weight management helps prevent worsening symptoms and associated conditions like diabetes and heart disease, and supports mental health.

Calocurb can be used alone, alongside GLP-1 RA medications, or as a transition tool when stopping them. It addresses the gut hormone disruption common in PCOS, where natural GLP-1 signalling is often impaired.

For educational guidance only. Developed in collaboration with practitioners. Not a substitute for medical advice. PCOS is a complex condition — always follow your healthcare provider's individualized recommendations.

Protocol

Managing Appetite Around Your Period

For women experiencing increased cravings and appetite in the premenstrual phase — whether you want to use Calocurb cyclically or daily.

Cyclical use (recommended for most)

Time of day Days 1–2 Days 3–4 Day 5+
AM — 1 hr before a meal
PM — 1 hr before a meal

Start about 7 days before your period and continue through the first few days. On your second cycle, if no laxative effect: start at 1 capsule × 2 meals, increasing to 2 capsules the next day. If you had a laxative effect: start 10 days before and ramp more gradually. For daily use, follow the standard step-up above.

Max 4 capsules daily. Best results on an empty stomach. You can also use Calocurb throughout your whole cycle if you prefer.

In the luteal phase (the ~2 weeks before your period), lower estrogen combined with rising progesterone significantly increases appetite. Studies show women eat over 200 calories more per day before and during their period — mostly sweet, high-fat foods.

For the 85% of women who experience PMS, cravings can be even more intense — potentially 500+ extra calories per day during peak craving time. Calocurb helps dampen this signal by boosting GLP-1, which reduces both appetite and "food noise".

For educational guidance only. Developed in collaboration with practitioners. Not a substitute for medical advice. Adjust timing based on your personal cycle and symptom patterns.

Protocol

Exercise & Food Noise Control

For people on long-term exercise programmes who find that sustained training increases hunger and undermines their nutrition goals.

Step-up dosing schedule

Time of day Days 1–2 Days 3–4 Day 5+
AM — 1 hr before a meal
PM — 1 hr before a meal
Max 4 capsules daily. Best results on an empty stomach. Take before the meals where you find hunger hardest to manage — typically post-workout.

Short-term exercise briefly suppresses ghrelin (the hunger hormone). But with sustained long-term training, the body adapts: ghrelin production increases as the body tries to compensate for the energy expended. This is why people who train regularly often find they eat more than they intend to — and undo the calorie deficit they've worked to create.

Calocurb addresses the other side of the equation by boosting GLP-1 — the satiety signal — helping you feel genuinely satisfied from appropriately sized meals after training.

For educational guidance only. Developed in collaboration with practitioners. Not a substitute for medical advice. Ensure adequate caloric and nutritional intake to support your training programme.

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