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The Secret to Calocurb's Success: Understanding Its Mode of Action

The Secret to Calocurb's Success: Understanding Its Mode of Action

Semaglutide injections releasing GLP-1 (glucagon-like peptide one) synthetics such as Wegovy and Ozempic are making headlines around the world as “miracle” weight-loss drugs, but we are increasingly hearing stories about the resulting negative side-effects and people who regain all the weight and more if they stop. These drugs are so in-demand that diabetes patients who really require this medication are not able to get their hands on it. The main question we get asked is - how does Calocurb compare?

The secret behind current ‘weight-loss’ drugs is an active ingredient called semaglutide which belongs to a group of GLP-1 receptor agonists, they work by mimicking the naturally occurring GLP-1 hormone; this is not the same as being a natural alternative to the human production of GLP-1.

GLP-1 is released in the gut after meals or when bitter receptors below your stomach are activated. The hormone acts on the pancreas to increase insulin secretion and decrease glucagon secretion (glucagon stimulates sugar production) in response to food, keeping blood sugar from rising too high. GLP-1 also slows down the rate of food leaving the stomach and into the small intestine and sends signals to your ‘reward centre’ part of the brain, decreasing appetite and cravings for foods. Once the active ingredient in Calocurb, Amarasate ® is released into the small intestine, it triggers a natural signal for stimulating natural GLP-1 release from specialised cells.

The long-term consequences of using semaglutide injectables such as Wegovy and Ozempic are not yet known, they’re expensive and recent research has found that ⅔ of all people using these semaglutide injectables rapidly regain the weight of what they lost during the first year after stopping the medication (1).

Maintaining weight loss after losing it is the difficult part - one in which the semaglutide injectables do not offer an effective solution unless you are willing to inject yourself weekly. The overall evidence-based answer states that while people lose weight while taking a semaglutide injectable in a dose-dependent and duration-dependent manner, they will tend to regain weight after medication is stopped. Calocurb is the only 100% completely natural and scientifically proven way to reduce caloric intake by 20% and up to a 100% reduction in increased hunger and craving in both men and women.


Wilding JPH, Batterham RL, Davies M, Van Gaal LF, Kandler K, Konakli K, Lingvay I, McGowan BM, Oral TK, Rosenstock J, Wadden TA, Wharton S, Yokote K, Kushner RF; STEP 1 Study Group. Weight regain and cardiometabolic effects after withdrawal of semaglutide: The STEP 1 trial extension. Diabetes Obes Metab. 2022 Aug;24(8):1553-1564. doi: 10.1111/dom.14725. Epub 2022 May 19. PMID: 35441470; PMCID: PMC9542252.

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